New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. Here are the many health benefits believed to be possible with Pycnogenol: Reduces "leaky" blood vessels by making the wall proteins (collagen, elastin) more resistant to damage. ", American Heart Association: Understanding Blood Pressure Readings., Iranian Journal of Public Health: "Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis. Improve cardiovascular health. Pycnogenol is the registered trademark name for a French formula. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. All rights reserved. from the bark of the French maritime pine tree. Its true. DOI: Gulati OP. Also, its important to note that some of these studies were funded by Horphag Research, the original developers and exclusive marketers of Pycnogenol. Thirty patients were treated with 150 mg of Pycnogenol a day and the other 10 patients with placebo for a period of two months. However, a study of 24 adults with ADHD found that pycnogenol did not improve ADHD symptoms better than placebo. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. A trial of 53 students found that pycnogenol may improve cognitive function, memory, attention, mood, and mental performance after 8 weeks [20]. For allergies: 50 milligrams twice daily. is a clickable link to peer-reviewed scientific studies. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. Note that the numbers in parentheses (1, 2, etc.) Dr. Eric L. Zielinski is a sought-after natural . Regulations set manufacturing standards for supplements, but that does not guarantee that they are safe or effective. (5). Memorial Sloan-Kettering Cancer Center web site: "About Herbs: Pine Bark Extract. A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. Mental function. In a good-quality study, 77 patients with osteoarthritis were treated with 100 mg of Pycnogenol daily and 79 patients were treated with placebo for three months. Most have similar amounts of active substances and are often sold under the brand name Pycnogenol [6]. The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD) [Abstract]. During the first month on L-arginine, only five percent of patients experienced normal erection. The standard dose appears to be 100-200 mg/day. Pycnogenol was featured on The Dr. Oz Show in January 2013, . Symptoms include swelling in ankles and legs, discolored skin and, if the skin is broken, the development of leg ulcers. In a study of 72 children undergoing cancer chemotherapy, Pycnogenol reduced painful mouth ulcers, both alone and in combination with vitamin E [79]. Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . . 2005 - 2023 WebMD LLC. In one human study, some of the reported side effects of chanca piedra supplementation included: abdominal pain. In the study, it reduced cold symptoms and complications, the number of lost working days, and the use of over-the-counter medications compared to those who did not supplement with the extract [60]. Berberine is a compound extracted from several plants. High levels of both of these are considered risk factors for heart disease. A clinically studied blend of Pycnogenol and a special bilberry extract (called Mirtogenol ) has been shown to provide benefits for vision and eye health. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. By clicking Subscribe, I agree to the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Becoming a Vegetarian: Foods to Choose From. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. Skin irritation. Researchers suggest that it may have stronger benefits than elastic compression stockings. Pine bark extract may be the perfect treatment since its an antioxidant dynamo. A study was conducted by the Guang An Men Hospital of Chinese Medical Science Research Institutewith 77 diabetes type II patients to determine if theextract of the French Maritime pine bark provided anti-diabetic effects. Since components of Pycnogenol can be modified during digestion and absorption as well as by the liver, diseases that affect the gut or liver may increase or decrease its effects [84]. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. You can gradually increase how much you take once you get a better idea of how your body reacts to it. Moreover, Pycnogenol lowered the chemical, leukotrienes responsible for asthma attacks. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. Pycnogenol is a patented extract of the French maritime pine bark (Pinus pinaster). A number of clinical trials suggest that Pycnogenol may lower blood glucose if taken daily for at least 12 weeks. In a study of 100 healthy women mostly in their early 40s with mild sexual dysfunction, a combination product with Pycnogenol (Lady Prelox) improved sexual function over 8 weeks [74]. Four hundred years later, a French researcher named Jacques Masquelier did some studies to understand why this natural remedy was so effective. He learned about the seemingly omnipotent antioxidant within it and how those antioxidants increase the absorption of vitamin C. Continued research showed that the pine bark contained flavonols and bioflavonoids, which hold tissue-repairing properties. Consequently, blood pressure is lowered. . 10 Ways to Control Blood Sugar without Medication, Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies, Reduces leaky blood vessels by making the wall proteins (collagen, elastin) more resistant to damage, Helps maintain high vitamin C and E blood levels for their antioxidant effects, Inhibits platelet aggregation like low-dose aspirin, Reduces hardening in the arteries by increasing nitric oxide production in blood vessels, leading to greater dilatation, Counteracts the damaging effects of ultraviolet radiation, Stimulates the immune system by boosting T and B cell functions, Protects brain cells from toxic chemicals. nausea. Pycnogenol (200 mg/day) may reduce muscle cramps and pain according to a study of 66 healthy people, athletes, and those with venous problems after 4 weeks. Plus, it reduced total and LDL (bad) cholesterol. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. There were 88 in the control group and 81 in the Pycnogenol group. Another one of its exemplary effects is helping manage blood pressure levels. The remaining compounds are phenolic acids, which may also have antioxidant activity [1, 2]. It may cause side effects such as: Risks. A Pycnogenol combination product (with l-arginine, alpha lipoic acid, B vitamins, and vitamin K2) may help protect the blood vessels and reduce high homocysteine levels, according to a trial of 25 people [39]. It also may help those on blood pressure medications to reduce their dose [32]. In a study of 33 people with severe osteoarthritis, pycnogenol (200 mg/day) reduced inflammatory markers after 3 weeks. Optimal doses of pycnogenol have not been set for any condition. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. Twenty-one patients were given Pycnogenol at 150 mg daily and 18 patients received no treatment for a period of eight weeks. Pycnogenol seems to help with asthma and allergies. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. Neuroprotective effect of Pycnogenol® following traumatic brain injury. It comes from the bark of a European pine tree. Pine bark extract contains active ingredients that can also be found in peanut skin, grape seed, and witch hazel bark. He later extracted proanthocyanidins from the European coastal pine tree, which he named Pycnogenol.. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [emailprotected]. As a skin powder, however, you can use it safely for up to six weeks. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. In this article, well summarize all the potential benefits and the scientific research surrounding pine bark extract and Pycnogenol. Therefore, those who have autoimmune conditions could see their symptoms increase after taking it., Since Pycnogenol is used for so many conditions, doses can vary. The Benefits of DIM. For most people, pine bark extract doesn't cause any side effects. Potential for allergy when taken orally or used on the skin. Pycnogenol (100 mg/day) may reduce hay fever symptoms, according to a clinical trial of 39 people. DOI: Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 50 to 450 milligrams of pine bark extract daily, Supplements During Pregnancy: Whats Safe and Whats Not, The ADHD Diet: What Works and What Does Not, Berberine A Powerful Supplement With Many Benefits, The Top Health Benefits of Prunes and Prune Juice, What to Know About Andrographis Supplements: Potential Benefits and Uses, Kerry Boyle D.Ac., M.S., L.Ac., Dipl. Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. However, research on these two groups is limited [71, 15]. If possible, try to get pine bark extract from a local supplier, such as a health food store. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli . If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. Comment * document.getElementById("comment").setAttribute( "id", "a79cdfe7a30d8f84d45d97f833c00b8c" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Diabetes-associated small blood vessel changes is the leading cause of diabetic ulcers. Pine bark extract appears to reduce the creation of free radicals, which are molecules linked to several skin conditions. The study concluded that Pycnogenol can prevent cramps, muscular pain at rest, and pain after/during exercise healthy people or those with diabetes or claudication. Lutein uses and benefits include helping prevent eye conditions like macular degeneration and cataracts, skin disorders and skin cancer, several types of cancer, including colon or breast cancer, type 2 diabetes, and heart disease. For children with ADHD, research suggests that symptoms start to return after about a month without taking maritime pine, so taking periodic breaks shouldnt make it any less effective. Pycnogenol (up to 200 mg/day) may improve asthma and reduce inflammatory asthma markers in the blood, leukotrienes, after 4 weeks, according to a randomized placebo-controlled trial of 26 asthma patients [14]. It also seems to help with cell regeneration and replication. WebMD does not provide medical advice, diagnosis or treatment. The study provided clear evidence that Pycnogenol does, indeed, offer photoprotection however, it came out even better than expected, showing that it may be used to reduce hyperpigmentation of human skin while improving the skin barrier function and extracellular matrix homeostasis. (6). 1 Anti-Aging Beverage, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, What Is a Marionberry? A randomized, double-blind, placebo-controlled study of 60 patients aged six to 18 years old, was conducted over three months during which patients were randomly assigned to receive either Pycnogenol or placebo. Pycnogenol reduced foot swelling in 79% of the patients, versus one percent in the placebo group. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), and phenolic acids, including derivatives of benzoic and cinnamic acids (2% to 4%). Various studies, referenced at uofmhealth.org, have shown that a daily dosage of Pycnogenol . But what makes this miracle ingredient so amazing? Quality and active ingredients in supplements may vary widely from maker to maker. Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. Some health benefits of Pycnogenol include:. 1 Anti-Aging Beverage, An surprisingstudy found that pine bark extract was far better than aspirin at inhibiting smoking-induced clotting, using lower amounts without the bleeding often found when using aspirin. Extracts can also be made from other pine barks, such as Pinus radiata, Pinus densiflora, Pinus thunbergii, and Pinus massoniana. Some people seek to manage ADHD symptoms through an ADHD diet. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Pycnogenol is a standardized supplement formula guaranteed to contain at least 65-75% proanthocyanidins, the active . The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. In a clinical trial of 116 women, Pycnogenol (60 mg/day) reduced menstrual pain and the need for additional painkillers, taken over 2 cycles. It has been studied for its effects on everything from mental function to treating high blood pressure. Set Ascending Direction. Research suggests that taking pycnogenol improves mental function and memory in both young adults and the elderly. Pycnogenol supplementation reduced skin redness from UV rays in a trial of 21 people over 8 weeks. Organika Pycnogenol 50mg 100 Tablets. No side effects were noted, unlike its synthetic counterpart. Along with the rest of the crew, he developed symptoms of vitamin-C deficiency. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. Chemistry. Pycnogenol French maritime pine bark extract's 4 basic properties. For people who have symptoms that are more severe, traditional medicine is probably more effective. In the study, women taking Pycnogenol were more satisfied and compliant to the regimen [24]. Pycnogenol (pic-noj-en-all) is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. Erectile dysfunction has increased over the past decade or two, creating a pathway for various medications to land on the shelves of numerous medicine cabinets. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. This condition is due to the pooling of blood in the veins of the lower legs. 1) Encourages Healthy Blood Pressure. Theres evidence that Pycnogenol may be a promising nootropic for various groups of people, including middle-aged professionals, students, and people with mild cognitive decline like brain fog. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. Pycnogenol in metabolic syndrome and related disorders [Abstract]. A clinical trial of 60 health professionals found that Pycnogenol (150 mg/day) may improve cognitive function, attention, mental performance and specific professional skills after 12 weeks. Results showed that one month of Pycnogenol led to a significant reduction of hyperactivity with improvement in attention and visual-motor coordination and concentration, as compared to no positive effects in the placebo group. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. In another study, Pycnogenol increased glutathione levels and total antioxidants after a month in children with ADHD [42, 43]. Ana has many years of experience in clinical research and health advising. We take a look at what the science actually says. Pycnogenol has been shown to help relieve the pain associated with osteoarthritis by keeping blood chemicals from attacking the cartilage. Natural Factors Pycnogenol 25mg 60 Veggie Caps. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. We avoid using tertiary references. Pycnogenol alleviated adverse effects in cancer patients, Pycnogenol improved working memory in older adults, Pycnogenol lowered the use of analgesic drugs in dysmenorrhea (severe menstrual pain), Pycnogenol reduced symptoms in endometriosis comparable to leuprorelin, the standard drug for this condition, Pycnogenol was found to be effective for sun-caused hyperpigmented skin, Pycnogenol reduced the inflammation in lupus patients, Pycnogenol reduced gingival bleeding and plaque formation. It also may enhance swimming, biking, and running scores in professional athletes preparing for a triathlon (at 150 mg/day). Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. 5) Inflammation and Allergies. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. Erythritol: Is This Healthy Sweetener the Real Deal? However, its always a good idea to start with a low dose so you can monitor how your body responds. This makes it very hard to set a standard dose. A deficiency can cause issues like anemia, stunted growth, heart problems and neural tube defects. L-arginine is more effective when paired with L-citrulline or pycnogenol to combat erectile dysfunction and improve exercise performance. Side effects. Another study found this supplement can even halt progression of vision . Headaches. Pycnogenol is the registered trademark brand name of French maritime pine bark extract. The women taking Pycnogenol also experienced improvement in fatigue, sleep, concentration, memory, dizziness, and mood, including less irritability. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. Used early on, it may prevent eye damage and blindness from diabetes [34]. (4). Rakel, D. Integrative Medicine, 3rd edition, Saunders, 2012. It does this by improving the time it takes the body to reach a fatigued state through increased serum NAD+ levels. (2006). Pine bark extract has been studied with regard to its ability to help diabetic patients. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. Tongkat ali is an herbal remedy suggested to treat various ailments, including low testosterone and male infertility. Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. Infants and children may not be able to synthesize enough of it, but it is present in many protein-rich . Speak with your doctor before supplementing. What gives pine bark extract its notoriety as a powerful ingredient and super antioxidant is that its loaded with oligomeric proanthocyanidin compounds, OPCs for short. A randomized placebo-controlled trial of 60 children with mild-to-moderate asthma found that those who took Pycnogenol may be able to reduce or discontinue their use of rescue inhalers more often than the placebo group [15]. A 2015 review indicates that pine bark extract can be used to treat metabolic syndrome and related disorders such as obesity, diabetes, and high blood pressure. Pycnogenol health benefits. Side Effects of Pycnogenol. 3. In the study, many of the participants on Pycnogenol reduced their dosage of high-blood-pressure medication (nifedipine) [37]. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. The results showed that the combination of local and systemic applications of Pycnogenol were the best in terms of ulcer healing even though local application of Pycnogenol also speeded up ulcer healing. It is chronic venous insufficiency, a common disease among people who are obese or elderly and those who lead a sedentary lifestyle. Lowers Blood Pressure. A clinical trial of 57 ADHD children found that daily Pycnogenol (1 mg/kg) for one month may reduce hyperactivity symptoms. Seems like it must be pretty amazing, but lets look closer. Today, I want to share with you my secrets to reduce sugar Top 7 Benefits of Green Tea: The No. COPD. ", Natural Medicines Comprehensive Database web site: "Pycnogenol.". - Apply a hot compress to the anus or soaking it in a shallow tub of hot water several times a day. Pycnogenol may have benefits for heart and artery health. ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. If you knew you could resolve your erectile dysfunction and, therefore, naturally remedy impotence issues, wouldnt you? A trial of 86 people with eye damage from diabetes found that antioxidant therapy (including pycnogenol, vitamin E, and Coenzyme Q10) may improve eye health and reduce reactive oxygen species levels [35]. A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. Helps maintain high vitamin C and E blood levels for their antioxidant effects. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body . Taking pine bark extract also increases the blood . Rare cases of liver disease. ( 1) 2. DOI: Chowdhury WK, et al. . Pycnogenol can help control blood pressure, which helps improve overall heart health. Clinical research suggests that Pycnogenol is possibly effective for improving athletic performance. According to a study of 170 women, low-dose pycnogenol (60 mg/day) may improve menopausal symptoms over 3 months, including night sweats, hot flashes, insomnia and sleep problems [69]. Eye health. (10), A 15-year Dutch study was published stating that 27,939 healthy female health professionals were given aspirin or a placebo for a period of time. There havent been enough studies yet to change practice protocols for treating children. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. editor, The Gale Encyclopedia of Alternative Medicine, third edition, 2009. A trial of 84 people found that both Pycnogenol oral supplements and creams (0.5%) may prevent hemorrhoids from bleeding during acute attacks after 7 days. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. If youre wondering how to get an even skin tone, there are plenty of remedies that can help. Can Pycnogenol help? Pycnogenol treatment reduced the need for painkillers by 58% versus one percent in the placebo-treated group. The following purported benefits of Pycnogenol are only supported by limited, low-quality clinical studies. More research is needed to see how this supplement affects all of these conditions. However, it can also be used topically. Pycnogenol led to a reduction of muscle cramps from 4.8 a week to 1.3 at week four. A small 2017 study examined the effects of pine bark extract in treating cardiovascular risk factors associated with menopause. These benefits appeared to persist for some time even after stopping supplementation [72]. Researchers suggest this benefit may be due to an increase in glutathione and SOD, two antioxidants that may reduce inflammation and oxidative stress in Crohns [76]. Its been noted that taking OPCs and vitamin C supplements at the same time could increase blood pressure if you have hypertension. Pycnogenol pine bark extracts contain a unique blend of flavonoids whose antioxidant action is over is 50 times more powerful than vitamin E, 20 times more powerful than vitamin C and 16 times more active than grapeseed extracts. However, some of these other pine bark extracts can have different active compounds, which may affect their biological activity. If you are taking blood thinners, do not take pine bark extract or Pycnogenol unless approved by your doctor. Pycnogenol treatment lowered the ACE-inhibitor dose required to control blood pressure, and lowered fasting glucose levels as well. If youre native to Oregon, you likely know all about marionberries. According to a meta-analysis of 9 trials including 549 people, 150-200 mg/day for at least 12 weeks may reduce both diastolic and systolic blood pressure [36]. Researchers suggest that it may have stronger benefits than elastic compression stockings. 1. are clickable links to these studies. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. In a small/preliminary study of kids with asthma, pycnogenol helped improve symptoms. Regardless, a natural option is available and far worth the wait. The list goes on a bit further, as the OPCs in thisextract may inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems, which basically means it may be a natural treatment for many serious health conditions, such as stroke and heart disease. Vinpocetine is a well-known substance in the health-hacking community with a variety of claimed health benefits. In the following sections, well discuss the common forms and dosages of Pycnogenol that are commercially available. Some small studies suggest it may also protect against coronary artery disease and blood clots. But, as you know, going for the natural approach can make a huge difference in overall health. Pycnogenol-treated patients had significant improvement in symptoms as well as a reduction in leg swelling as compared to those not receiving treatment.
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