% \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! However, consumption of large quantities of the material may have a laxative effect. Cellulose microcrystalline. All rights reserved. PDF (2.77 mb) 2021 FMC Sustainability Report. Test Data Available. Page 1 of 8. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. %PDF-1.4 Chemical Formula: (C6H10O5)n 1.4. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. EINECS #: 232-674-9 1.7. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . No. Date Approved: 05/25/2010. Battista, O. Instead, they obtained a stable colloidal suspension. . Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. PharmaCentral 2021 . Explore how you can develop your career and bring your creative ideas to life at IFF. No. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Gloves, eye protection and a dust mask should be used. MATERIAL SAFETY DATA SHEET. Fiber supplements can lessen the absorption of some . The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. stream Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. We are artists at heart and creators by nature. <> cas:9000-11-7 msds Carboxymethyl cellulose. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. MATERIAL SAFETY DATA SHEET Version: 1.0 1. Microcrystalline Cellulose. CAS #: 9004-34-6 MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. >> CAS #: 9004-34-6 1.6. <> 2 0 obj Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. MCC helps in the formation of spheres because of its . %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. % Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. 6 0 obj The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Microcrystalline Cellulose (MCC) Manufacturing Industry. %PDF-1.4 Microcrystalline Cellulose (MCC) MSDS 1. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. It is a white, free-flowing powder. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Browse Avicel PH-101 and related products at MilliporeSigma. endobj LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . We respect your privacy FMC Privacy Policy. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Go to Investor Relations. 4. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Truly distinctive drug delivery solutions. q9;v80q>jZ Terms and Conditions Compliance Solutions Industries About 3E News & Events . These grades have particle sizes ranging from <30 to approximately 200. Earth Supplied Products LLC. /Contents 4 0 R Molecular Weight null. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. (&E. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. The figure below illustrates the structural organisation of cellulose within plants. HMo@9, U Q!R/1*;` Biologicals by FMC. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. It is hygroscopic and insoluble in water. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Microcrystalline Cellulose / Avicel PH-102. 130. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Regulatory Information Looking for FMC'searnings news? ( PDF (4.11 mb) Footer menu 1. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Product and Company Identification . The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. 9,LL!z /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Safety Data Sheet (SDS) Viewer. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Avicel Microcrystalline Cellulose Physical Properties. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Wu, K. Zuurman, H.W. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. It is, however, a good source of fibre. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. FMC Corporation. : 5. If you are already a ChemPoint customer then sign up for access to our online ordering website. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. CAS #: 9004-34-6 . Well-recognized product that can do it all. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. pH 6.0 to 8.0 . : CL-611NF Date Approved: 01/13/2010. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. The most. Learn about FMC's differentiated biologically-based crop solutions. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. [FMC Study Number I92-1464]. Explore how we work and why we apply science and creativity for a better world to everything we do. 1 0 obj 6 DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. CoA. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Protect them from sunshine or rain. (1962). They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. endobj However, it yields non-digestible fibre. PDF (28.38 mb) 2022 Corporate Fact Sheet. Hi, let us know if you have any questions as you visit our website. Product Name: Microcrystalline Cellulose 1.2. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W 1. . $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? : 51395-75-6 Date Approved: 01/31/2008 Revision No. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. >> IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Trademarks: Avicel PH-102. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. }o]X4]. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. MSDS Ref. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. cas:9032-51-3 msds CELLULOSE PAB. Production of Pharmaceutical Grade Microcrystalline Cellulose. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Packaging: 34 x 50 kgs fiber drums. BIOACCUMULATIVE POTENTIAL Watch Now. Microcrystalline Cellulose / Avicel PH-102. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. << {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. B;vLZpHU%ChUyD+[ The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. 8 0 obj LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables.
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