x=3 t^2 IACUCs may allow quick decapitation with scissors for euthanasia of altricial rodent neonates (up to ten days of age). The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Pioneers cut bricks from sod-basically, prairie soil as a matrix, and grass and its root system as reinforcement. The IP injection site is on the animal's right side, close to the midline, in a caudal quadrant of the abdomen. Which of the following methods is considered acceptable for euthanizing mice? Which statement about the Occupational Health and Safety Program is false? B. Techniques for creating transgenic animals D The federally mandated search for alternatives helps to fulfill the requirement set forth in the AWA policies to consider alternatives to procedures that may cause more than momentary pain or distress. A. No treatment is available should a human become exposed. The investigator Which of statement is true about the euthanasia of neonatal mice? D. Notify the Institutional Official. Over distension of the urinary and gall bladders. C. While under anesthesia, mice should be monitored for cardiovascular and respiratory function and body temperature. Right on! Which of the following statements regarding the use of restraint on animals in a research study is FALSE? Your research must comply with the Guide for the Care and Use of Laboratory Animals if: Your institution receives funds from the National Institutes of Health (NIH). A. These institutions volunteer to participate in AAALAC's program, in addition to complying with the local, state and federal laws that regulate animal research. D. They become less stringent. This section explains the subject of divorce law in New Jersey. What group determines if a euthanasia method is acceptable for use in a particular species? Which of the following statements is TRUE? Methods of euthanasia deemed "acceptable with conditions" may require scientific justification before IACUC approval. Give the BNAT exam to get a 100% scholarship for BYJUS coursesNo worries! C If an IACUC votes to suspend a protocol or animal activity, its decision cannot be overturned by any administrator at the organization (including the Institutional Official). Mouse urine and pelt proteins are an allergic hazard to people. The Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. A. C. Sponsors a voluntary accreditation program for animal care and use programs. Explain why this approach was successful. Who is authorized to overturn a decision by an IACUC to suspend an activity involving animals? A Good practice when performing infectious disease work in animals includes working with hand covers; obtaining an antimicrobial sensitivity panel for the infectious agent; anesthetizing or sedating animals to reduce chances of accidental human needle sticks; and completing work in pairs. Permission should be obtained from the IACUC and clinical administrators responsible for the area. C AAALAC International (2017) describes itself as "a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. D. The research technicians who perform the animal experiments. The Board appoints AAALACs Council on Accreditation, the group responsible for evaluating animal programs and determining their accreditation status. Major survival surgery on non-rodent mammals For example, when we wink at someone, offer a strong handshake or back away, we are Pheochromocytomas are catecholamine-secreting neuroendocrine tumors. In this edition, we will bring you up to speed on AO VET activities over the past five months. B. Non-survival A Because they have potential to be used in biological warfare, select agents are given additional regulatory oversight by the CDC. All of the following are practical methods of identifying mice EXCEPT: When producing monoclonal antibodies in vivo, what parameter should be considered? Which of the following sets of IACUC members are required by the AWA and/or PHS? APPROXIMATELY 685 INSTITUTIONS ARE IN NORTH AMERICA, 111 INSTITUTIONS IN EUROPE, 13 INSTITUTIONS IN LATIN AMERICA AND THE CARIBBEAN, B Per PHS Policy and USDA Animal Welfare Regulations, the IACUC is given responsibility for ensuring that research personnel are properly trained to perform animal procedures. C. Survival Either general or regional (local) anesthesia is required to prevent pain. Accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International has long been trumpeted as being the "gold standard" The Council conducts on-site visits and extensive evaluations, and provides ongoing advice to help organizations achieve and maintain accreditation. C. Dogs and cats C A mandated IACUC function is to conduct reviews of the animal care and use program on a semiannual basis. C. The lateral saphenous vein is not accessible in the mouse. The Council is pleased to inform you that the program conforms with AAALAC International standards as set forth by the Guidefor the Care and Use of Laboratory Animals, NRC 2011. Therefore, FULL ACCREDITATION shall continue. What does "IACUC" stand for? A. The program started in 1965, when leading veterinarians and researchers organized the American Association for Accreditation of Laboratory Animal Care, or AAALAC. Describe the fluid-mosaic model of membrane structure. A As a prey species, rodents are genetically programmed to mask signs of pain or distress. C. USDA regulations require that all mice be fasted prior to surgery. Surgical procedures should be planned and approved by the IACUC before they are performed. Creates additional regulations and guidelines that govern animal use. D. Animals must be moved to larger cages. D. Animal and Plant Health Inspection Service (APHIS), B According to PHS (2015), OLAW "has responsibility for the general administration and coordination of the Policy, provides specific guidance, instruction, and materials to institutions that must comply with the Policy.". The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. A. Enrollment in the institutional Occupational Health and Safety program is mandatory before working with animals. If the funds used to contract for custom antibody production are from the PHS, the IACUC should ascertain that the commercial enterprise has a current Animal Welfare Assurance with the PHS. Institutional Animal Control and Use Committee AAALAC International leads the way in global accreditation for EN. AAALAC Accreditation demonstrates to funding agencies and the general public that the animal care provided goes beyond minimum regulatory requirements. Which of the following is considered a minor change that would not require formal IACUC review and approval? Which of the following organizations must comply with the PHS Policy when utilizing vertebrate animals for research, teaching, or testing? For some, animal research is a controversial topic. Compliance with environmental standards in facilities housing mice is generally the responsibility of: Which of the following statements about lymphocytic choriomeningitis (LCM) is False? Endpoint criteria describe when it is time to do what? Driving in the summer, winter, or rainy season may be to blame for the unpleasant odor inside the car. Blood collections should be spaced far enough apart to prevent which of the following? https://quizlet.com/393848410/animal-research-certification-test-flash-cards D. History and tactics of animal activist groups (such as PeTA and HSUS). Which of the following represents an appropriate technique for subcutaneous injections in mice? Experimental criteria are the only determinants of the euthanasia method that is acceptable for an animal. Which of the following statements is true regarding research antibody production? The needle tip should be inserted behind the incisors. D. The organization, investigators, animals, and public health and welfare. Long-term anesthesia is best achieved by repeat dosages of a short-acting injectable anesthetic cocktail. Ignore the size of the hot air inlet vent. Accredited D. The selection of an appropriate euthanasia method should address considerations of humaneness to the animal, safety for the staff and onlookers, and experimental needs. C. Over enthusiastic grooming of dorsal fur or haircoat. They do not apply to nonrecombinant ones. Which is TRUE regarding thermal support for mice during anesthesia? In the 1950s, the Professional Standards Committee of the Animal Care Panel (ACP), now the American Association for Laboratory Animal Science (AALAS), recognized a need for assuring the general public that laboratory animal research was conducted on a professional level, and that standard procedures were applied. To track for the presence of pain or distress in mice over time, the baseline should be based on: The signs observed on normal, untreated animals. Association for Assessment and Accreditation of Laboratory Animal Care International, Learn how and when to remove these template messages, "Association for Assessment and Accreditation of Laboratory Animal Care International", Learn how and when to remove this template message, Physicians Committee for Responsible Medicine, American Association for Laboratory Animal Science, https://en.wikipedia.org/w/index.php?title=Association_for_Assessment_and_Accreditation_of_Laboratory_Animal_Care_International&oldid=1054465657, Animal welfare organizations based in the United States, Articles lacking reliable references from May 2008, Articles needing additional references from October 2021, All articles needing additional references, Articles with multiple maintenance issues, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 10 November 2021, at 05:42. Fell free get in touch with us via phone or send us a message. Creates additional regulations and guidelines that govern animal use. The IACUC's activities to ensure compliance benefit whom? In fact, if an IACUC votes to suspend a protocol or animal activity, that decision cannot be overturned by any administrator at the organization. A. Number of animals approved by the IACUC for a particular protocol. A Category E of the USDA report form applies to " animals upon which teaching, experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures, results, or interpretation of the teaching, research, experiments, surgery, or tests.". The use of a new anesthetic that provides better induction and a shorter recovery period. A. Which of the following statements concerning health risks from working with mice is false? A. Which of the following would provide longer-acting pain relief in mice? B. Which of the factors below affect the routine sanitation schedule in animal facilities? B. On this Wikipedia the language links are at the top of the page across from the article title. $$ B. USDA (Animal Care Section) A. Which of the following is not a justification for single housing social animals? In the mouse, IP injection should proceed only after aspiration has shown that the needle is properly positioned. Those organizations that conduct wildlife research. They are methods that are acceptable as a follow-up procedure for ensuring death. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be One book, The Guide for the Care and Use of Laboratory Animals serves as the basic standard represented by AAALAC accreditation. Which of the following activities WOULD place an animal in category E? (This is also called an exclusive or.). Investigators should enroll in the local Occupational Health and Safety Program before beginning work with laboratory animals. A. Injectable agents cause a greater depression of respiration in rodents. A. B Collection of blood by cardiac puncture can result in bleeding into the pericardial sac and tamponade (death), and should only be done terminally. A. B. Anesthetize or sedate animals to reduce the chances of accidental human needle sticks. What potential problem(s) should you be aware of when mice are undergoing surgical procedures? Because of potential damage to the heart, blood collection by cardiac puncture is usually permitted only as a terminal procedure. The IACUC can exempt an animal for scientific reasons. The USDA requires documentation of all postoperative care and retention of records for one year after the death of the animal. Post-operative analgesics should be used and daily post-procedural monitoring done by personnel familiar with rodent behavior. Research utilizing animals is a privilege, not a right, and the IACUC has the responsibility to ensure that research, testing, and educational activities involving the use of animals are performed according to the highest standards. Studies in which animals are allowed to die without pain relief. C. Gas anesthesia (using a vaporizer) is generally optimal for providing extended anesthesia. B. The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments? Assist with writing the basic science portions of a grant application C. Commercial antibody enterprises are not required to follow PHS or USDA guidelines. The hot air inside the balloon is at $70^{\circ} \mathrm{C}$ and $1 \mathrm{~atm}$. Which of the following is true regarding the IACUCs authority and responsibilities regarding research animal misuse, mistreatment, or noncompliance? B. A. UsingAAVrh10,Raetal.achievedgreaterefcacyin mice by either increasing the dose via combined route of administration,27 combination of systemic AAVrh10 with . Which of the following is true of the dog exercise program mandated by the AWR? This concept represents the beginning of the effort to form an accreditation program for laboratory animal care and use. Which of the following is TRUE regarding the Animal Welfare Regulations and duplication of experiments? A. What diameter spherical balloon will just support the total weight? The organization and regulatory agencies only If an organization accepts PHS funds or is registered with the USDA as a research organization, any protocol suspension does not have to be reported by the Institutional Official to OLAW and USDA. Julie S Snyder, Linda Lilley, Shelly Collins, Explain the important distinctions between **periods and groups of the periodic table**. Which statement is true regarding venipuncture procedures in mice: AAALAC accreditation also promotes scientific validitywhen research involves animals, reliable results depend on healthy animals and superior animal care. An agent that has high individual risk but low community risk would be in which Risk Group per the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules? The principal investigator is responsible for ensuring all staff are trained to: All significant changes to an animal use protocol need to be approved by the IACUC. Which of the following falls within the range of the total blood volume of adult mice? They become more vague Institutional Animal Care and Use Committee. The various behavioral forms that nonverbal communication takes are referred to as nonverbal, Why give alpha blocker before beta blocker in pheochromocytoma. B. Once a report of mistreatment, misuse, or noncompliance is received, the AWR and PHS Policy require the IACUC to review and investigate the allegations (if warranted). Which of the following Guides is best used as a source of guidance for animals used in agricultural research and teaching? A. Hamsters and gerbils. B According to the AWR (3.81.d. In this diverse landscape, AAALAC International uses performance standards to assure harmonization of accredited animal care and use programs globally.
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