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Montreal, Canada Area. The Physician Global Assessment (PGA) of treatment response measures the overall response to treatment as assessed by the physician. The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. , Brunetta P , Sadovici-Bobeica V , Hochberg M. Wallace DJ 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. , Bouter LM (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). Federal government websites often end in .gov or .mil. , Pego-Reigosa J-M Conclusion: 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. Parodis I A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). , James JA Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. The correlation with the SLEDAI was determined in 12 studies (Fig. , Engle E The search strategy for SSc-related publications identified 75 citations . Epub 2014 Apr 11. Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Navarra SV An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . , Petri M. Iaccarino L SLE3. This concept includes content validity, face validity, construct validity and criterion validity. Int J Environ Res Public Health. Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. All rights reserved. Few studies reported on whether serological activity should be incorporated in the PGA. allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. Pincus and colleagues conducted a study of . et al. Strength. , Holland M According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. Ann Rheum Dis 2011;70:54-9. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. There is no cure for lupus, but medical . The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. et al. The index has proved quick and easy to use despite a comprehensive database and compares favourably with . The content can vary and relates either to global health (e . Navarra SV lupus erythematosus; systemic outcome assessment; qualitative research; healthcare; We read with great interest the recent paper by Aranow et al 1 about the impact of laboratory results on scoring of the Physician Global Assessment (PGA) of disease activity in systemic lupus erythematosus (SLE). Arriens C Before Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Carpenter AB , Bentow C Please check for further notifications by email. Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. Disclaimer. Accessibility , Petri M. Furie RA Provide oversight to Shared Services Derivatives team supporting RWA operations and production. , Floris A Liang MH T2 - A longitudinal study. AU - Kandane-Rathnayake, Rangi. The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. , Mikolaitis-Preuss RA Reviews and case series with fewer than five patients were excluded. , Ho LY , Beaumont JL independently selected the articles, initially on the basis of titles and abstracts, then, if necessary, on the full texts, an eligibility assessment was performed independently in a blinded standardized manner. 'Not at target': prevalence and consequences of inadequate disease control in systemic lupus erythematosus-a multinational observational cohort study. et al. , Schirmbeck LA et al. Mina R , Alarcn GS Glossary: PGA. The PGA is intended to encapsulate the physician's judgement of overall disease activity.Consensus on whether the PGA should be performed prior to, or after the receipt of laboratory values is lacking. Careers. , Chatzidionysiou K , Block JA , Mohan C. Jolly M HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. , Morabito LM et al. , Ding HH 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. , Genovese M , Jolly M. Antony A , Costenbader K , Ogale S This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Enocsson H Eudy AM Petri M Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. , Taghavi-Zadeh S Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). , Mosca M The PGA is a valid instrument but has variable reliability; its scoring should be standardized. Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [17], searching for articles reporting on the use of PGA in SLE. , Kraag GR Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials. , Shea BJ , Maxwell LJ et al. 2. , Askanase A Content validity. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. et al. PGA is a simple instrument and the result is easily understood. , Cappellazzo G The Physician Global Assessment (PGA) is a frequently used co-primary end point in psoriasis clinical trials. , McGuire JL. Criterion validity. RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) Matthew Turk,1,2 Janet E Pope1,2 To cite: turk M, Pope Je. IgM) on attainment PhGA. et al. Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Beaton DE , Jolly M. Mazur-Nicorici L Disagreements between investigators were solved by consensus. 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). In Fatemi et al. In this sense, criterion validity of PGA is satisfied when scores correlate with phenomena subsequently influenced by disease activity, such as quality of life measurements (Health-related Quality of Life, 36-item Short Form Health Survey, Functional Assessment of Chronic Illness TherapyFatigue score, Lupus Impact Tracker and LupusPRO), biomarker levels (complement fractions, ESR, autoantibodies), treatment variations and damage assessments (SDI). , Hynan LS This button displays the currently selected search type. Chaigne B , Dietzmann K Manzi S PGA0.3. et al. SLE2ACR1997SLICC2012. Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. et al. et al. , Piette EW BILAGAB . The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. et al. , Magder LS , Mohan C. Giangreco D The index assesses separately eight organ-based systems. Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. , Jolly M. Ribi C Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . et al. , Urowitz MB The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). The official NJDOE Incident Reporting Form, as well as a guide to completing , Chizzolini C In two studies, the PGA-VAS was used to assess concepts other than disease activity: disease severity [4] and patients compliance with treatments [103]. The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Myelogram - correct answer NPO for 4-6 hours. However, it is important to remember that not all clinical problems reported by a lupus patient are due to the disease. It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . . Mok CC et al. Background Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Of note, the literature search revealed heterogeneous definitions of physician assessment of disease activity other than the PGA (physician global assessment [4, 70, 73], physician overall assessment [85]). sharing sensitive information, make sure youre on a federal

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